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|Title:||Iron-catalyzed cross-coupling between 1-Bromoalkynes and grignard-derived organocuprate reagents||Authors:||Castagnolo, Daniele
|Issue Date:||2010||Project:||None||Journal:||EUROPEAN JOURNAL OF ORGANIC CHEMISTRY||Abstract:||
An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
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