Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5664
Title: Specific interactions of Bi(III) with Cys-Xaa-Cys unit of a peptide sequence
Authors: ROWINSKA ZYREK, M
Valensin, Daniela 
Szyrwiel, L
Grzonka, Z
Kozlowski, H.
Issue Date: 2009
Project: None 
Journal: DALTON TRANSACTIONS
Abstract: 
The medicinal application of bismuth compounds is focused in two fields: antimicrobial and anticancer. Bi(III) complexes have been used in medicine as an effective treatment of microbial infections, such as peptic ulcers, diarrhoea, gastritis and syphilis. 212Bi and 213Bi are strong a-particle emitters, which, bound to specific ligands, could be promising targeted radio-therapeutic agents for the treatment of cancer. In this work, the coordination of bismuth to three peptides with the Cys-Xaa-Cys motif was studied by potentiometric, spectroscopic, mass spectrometric and NMR methods. We have shown, that sulfur atoms from cysteines are critical donors for the coordination of Bi(III). Our investigation provides insight towards an understanding of the chemistry of bismuth-containing complexes and may lead to the further application of this metal in medicine.
Description: 
26954
URI: http://hdl.handle.net/20.500.12779/5664
ISSN: 1477-9226
DOI: 10.1039/b913430a
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