Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5657
DC FieldValueLanguage
dc.contributor.authorValensin, Danielaen_us
dc.contributor.authorSzyrwiel, L.en_us
dc.contributor.authorCamponeschi, Francescaen_us
dc.contributor.authorROWINSKA ZYREK, Men_us
dc.contributor.authorMolteni, Een_us
dc.contributor.authorJankowska, Een_us
dc.contributor.authorSzymanska, Aen_us
dc.contributor.authorGaggelli, Elenaen_us
dc.contributor.authorValensin, Giannien_us
dc.contributor.authorKozlowski, H.en_us
dc.date.accessioned2021-03-30T15:54:10Z-
dc.date.available2021-03-30T15:54:10Z-
dc.date.issued2009-
dc.identifier.issn0020-1669en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5657-
dc.description35714en_US
dc.description.abstractThe homeostasis of metal ions, especially copper and zinc, is a major factor that may influence the prion diseases and the biological function of prion protein (PrP). The His-rich regions are basic sites for metal binding and antioxidant activity of the PrP structures. Animal prion-like proteins contain also His-rich domains, and their coordination chemistry may provide better insight into the chemistry and biology of PrP structures and related diseases. Herein, we report an equilibrium study on heteronuclear Zn2+-Cu2+ complexes with zrel-PrP fragments from zebrafish. Potentiometric, spectroscopic, and mass spectrometric methods showed that the binding of copper is much more effective than the binding of zinc. At physiological pH, both metals bind to the histidine imidazole N donors of the studied peptides.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofINORGANIC CHEMISTRYen_US
dc.titleHeteronuclear and homonuclear Cu2+ and Zn2+ complexes with multihistidine peptides based on zebrafish prion-like proteinen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/ic9008202en_US
dc.identifier.scopus2-s2.0-68149091573en_US
dc.identifier.isiWOS:000268174800041en_US
dc.relation.volume48en_US
dc.description.firstpage7330en_US
dc.description.lastpage7340en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4187-3919-
crisitem.author.orcid9810-
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