Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5652
Title: Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes
Authors: Spreafico, Adriano
Chellini, Federico
Frediani, Bruno
Bernardini, Giulia 
Niccolini, Silvia
Serchi, T
Collodel, Giulia
Paffetti, Alessandro 
Fossombroni, V
Galeazzi, Mauro
Marcolongo, R
Santucci, Annalisa 
Issue Date: 2009
Project: None 
Journal: JOURNAL OF CELLULAR BIOCHEMISTRY
Abstract: 
The aim of the present study was to demonstrate the mitogenic and differentiating properties of platelet-rich plasma releasates (PRPr) on human chondrocytes in mono- and three-dimensional cultures. In order to assess if PRPr supplementation could maintain the chondrocyte phenotype or at least inhibit the cell de-differentiation even after several days in culture, we performed a proteomic study on several cell cultures independently grown, for different periods of time, in culture medium with FCS, human serum (HS), and releasates obtained from PRP and platelet-poor plasma (PPP). We found that PRP treatment actually induced in chondrocytes the expression of proteins (some of which novel) involved in differentiation.
Description: 
34965
URI: http://hdl.handle.net/20.500.12779/5652
ISSN: 0730-2312
DOI: 10.1002/jcb.22344
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