Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5638
Title: Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase
Authors: Manetti, Fabrizio 
Cona, A
Angeli, L
Mugnaini, Claudia 
Raffi, F
Capone, C
Dreassi, Elena 
ZIZZARI A., T
Tisi, A
Federico, R
Botta, Maurizio 
Issue Date: 2009
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Previous studies on agmatine and its derivatives suggested that the presence of hydrophobic groups on the guanidine moiety was a crucial key for inhibitory activity of maize polyamine oxidase. Accordingly, new lipophilic agmatine and iminoctadine derivatives were synthesized and tested for their ability to inhibit this enzyme. Several compounds showed an affinity in the nanomolar range, while a cyclopropylmethyl derivative of iminoctadine was found to be the most potent inhibitor of maize polyamine oxidase reported so far (Ki = 0.08 nM).
Description: 
36233
URI: http://hdl.handle.net/20.500.12779/5638
ISSN: 0022-2623
DOI: 10.1021/jm900371z
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.