Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5633
Title: Synthesis of New Linear Guanidines and Macrocyclic Amidinourea Derivatives Endowed with High Antifungal Activity against Candida spp. and Aspergillus spp.
Authors: Manetti, Fabrizio 
D., Castagnolo
F., Raffi
A. T., Zizzari
S., Rajamaki
S., Darezzo
P., Visca
A., Cona
M. E., Fracasso
D., Doria
B., Posteraro
M., Sanguinetti
G., Fadda
Botta, Maurizio 
Issue Date: 2009
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
New linear and cyclic guanidines were synthesized and tested in vitro for their antifungal activity toward clinically relevant strains of Candida species, in comparison to fluconazole. Macrocyclic compounds showed a minimum inhibitory concentration in the micromolar range and a biological activity profile in some cases better than that of fluconazole. One macrocyclic derivative was also tested against Aspergillus species and showed high antifungal activity comparable to that of amphotericin B and itraconazole.
Description: 
37874
URI: http://hdl.handle.net/20.500.12779/5633
ISSN: 0022-2623
DOI: 10.1021/jm900760k
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