Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5630
Title: Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)
Authors: H., Kozlowski
A., JANICKA KLOS
J., Brasun
Gaggelli, Elena 
Valensin, Daniela 
Valensin, Gianni 
Keywords: Copper; Iron; Zinc; Metal homeostasis; Metal transport; Regulation of metals; Diseases affected by metals
Issue Date: 2009
Project: None 
Journal: COORDINATION CHEMISTRY REVIEWS
Abstract: 
Metal ions, especially with high chemical activity (e.g. redox-active Cu and Fe) must be carefully managed in biological systems. The “uncontrolled” activity, e.g. catalysis of Fenton-like reactions by ions like Cu(I) or Fe(II), is so damaging for the biological milieu that right from their entry, metal ions need to be strictly controlled until they arrive at their storage site. This chaperoning occurs usually by proteins which are involved in transport, delivery and distribution processes. In this reviewsome aspects of the metal homeostasis for major metal ions (Cu, Fe, and Zn) are presented. The impact of these metals on some disorders are also discussed.
Description: 
36585
URI: http://hdl.handle.net/20.500.12779/5630
ISSN: 0010-8545
DOI: 10.1016/j.ccr.2009.05.011
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