Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5628
Title: Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile
Authors: Bova, S
Saponara, Simona
Rampa, A
Gobbi, S
Cima, L
Fusi, Fabio 
Sgaragli, GIAN PIETRO
Cavalli, M
DE LOS RIOS, C
Striessnig, J
Bisi, A.
Issue Date: 2009
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
L-Type Ca(2+) channels (LTCCs) play a key role in the regulation of vascular smooth muscle contraction, and substances that interfere with their function (Ca(2+) channel blockers) are widely used in the therapy of hypertension. Here, we report anthracene-maleimide derivatives as new LTCC blockers. Among these, 3, lacking intracellular effects, was investigated in more detail. The results show that 3 binds preferentially to inactivated LTCCs, directly interacting with the pore-forming subunit of the channel.
Description: 
36492
URI: http://hdl.handle.net/20.500.12779/5628
ISSN: 0022-2623
DOI: 10.1021/jm801589x
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