Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5623
Title: The Mitogen-Activated Protein Kinase Scaffold KSR1 is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse.
Authors: Giurisato, Emanuele 
Lin, J.
Harding, A.
Cerutti, E.
Cella, M.
Lewis, R. E.
Colonna, M.
Shaw, A. S.
Keywords: MAP Kinase; scaffold molecule; immune synapse
Issue Date: 2009
Project: None 
Journal: MOLECULAR AND CELLULAR BIOLOGY
Abstract: 
KSR1 is a mitogen-activated protein (MAP) kinase scaffold that enhances the activation of the MAP kinase extracellular signal-regulated kinase (ERK). The function of KSR1 in NK cell function is not known. Here we show that KSR1 is required for efficient NK-mediated cytolysis and polarization of cytolytic granules. Single-cell analysis showed that ERK is activated in an all-or-none fashion in both wild-type and KSR1-deficient cells. In the absence of KSR1, however, the efficiency of ERK activation is attenuated. Imaging studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse.
Description: 
27225
URI: http://hdl.handle.net/20.500.12779/5623
ISSN: 0270-7306
DOI: 10.1128/MCB.01421-08
Appears in Collections:Publications

Show full item record

Page view(s)

286
Last Week
84
Last month
8
checked on May 17, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.