Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5614
Title: Interaction Study of Bioactive Molecules with Fibrinogen and Human Platelets Determined by 1H-NMR Relaxation Experiments
Authors: Bonechi, Claudia 
Rossi, Claudio 
C., Rossi
Issue Date: 2009
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Abstract: 
In order to investigate the interaction processes between bioactive molecules and macromolecular receptors NMR methodology based on the analysis of selective and non-selective spin–lattice relaxation rate enhancements of ligand protons was used. The contribution from the bound ligand fraction to the observed relaxation rate in relation to macromolecular target concentration allowed the calculation of the normalized affinity index in which the effects of motional anisotropies and different proton densities have been removed. In this paper, we applied this methodology to investigate the affinity of epinephrine and isoproterenol towards two different systems: fibrinogen and platelets.
Description: 
36232
URI: http://hdl.handle.net/20.500.12779/5614
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2008.12.063
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