Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5608
Title: 1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation
Authors: M., Biava
G. C., Porretta
G., Poce
A., DE LOGU
R., Meleddu
E., DE ROSSI
Manetti, Fabrizio 
Botta, Maurizio 
Issue Date: 2009
Project: None 
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
During the search of novel antitubercular drugs related to BM 212, new diarylpyrroles were designed and synthesized on the basis of a structure–activity relationship analysis of many pyrroles previously described by us. Among them, 1-(4-fluorophenyl)-2-ethyl-3-(thiomorpholin-4-yl)methyl-5-(4-methylphenyl)-1H-pyrrole (2b) proved to be particularly active, with a minimum inhibitory concentration (MIC, expressed as μg/mL) and a protection index (PI) better than or comparable to those of reference compounds. Also the remaining compounds were very active, although their MIC and PI were in general lower than those of their parent 2-methyl analogues.
Description: 
38506
URI: http://hdl.handle.net/20.500.12779/5608
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2009.06.005
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