Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5593
Title: Mechanisms of Action and Chemical-Biological Interactions Between Ozone and Body Compartments: A Critical Appraisal of the Different Administration Routes
Authors: Bocci, Velio
Zanardi, Iacopo
Michaeli, D.
Travagli, Valter 
Keywords: Ozonetherapy, oxidative stress, antioxidants, ozone tolerance, hormesis, vascular diseases
Issue Date: 2009
Project: None 
Journal: CURRENT DRUG THERAPY
Abstract: 
After a long initial stage obscured by empirism and misconceptions, oxygen-ozonetherapy has now become a scientific discipline where the reactions between ozone and human blood are within the realm of orthodox biochemistry, physiology and pharmacology. Most of the basic mechanisms of action have been clarified and ozone can be considered a pro-drug, which almost instantaneously reacts with antioxidants and unsaturated fatty acids. These reactions generate the actual ozone messengers represented by either hydrogen peroxide as a fast acting compound or a variety of lipid oxidation products as late effectors. While ozone is totally consumed, micromolar amounts of these messengers are able to enhance the delivery of oxygen via erythrocyte activation, the immune system by a bland leukocyte stimulation and most of the remaining body cells by up-regulating the antioxidant system. The hazard of ozone toxicity has been dispelled by using the gas only within a dose range perfectly calibrated against the potent blood antioxidant capability. Ozonetherapy can be very useful in patients with chronic vascular disorders and ischemic problems and should be extensively used by official medicine. An extraordinary facet of ozone is its medical application versatility, as represented by several administration routes, and the minimal cost of this drug.
Description: 
20688
URI: http://hdl.handle.net/20.500.12779/5593
ISSN: 1574-8855
DOI: 10.2174/157488509789055045
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