Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5590
Title: Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors
Authors: S., Rajamaki
Innitzer, Anna
Falciani, Chiara
Tintori, Cristina
F., Christ
M., Witvrouw
Z., Debyser
Massa, Silvio
Botta, Maurizio 
Keywords: HIV-1; Integrase inhibitors; SAR study; Thiobarbituric acid; Rhodanine; Thiohydantoin
Issue Date: 2009
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
Description: 
22526
URI: http://hdl.handle.net/20.500.12779/5590
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2009.04.132
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