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|Title:||Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors||Authors:||S., Rajamaki
|Keywords:||HIV-1; Integrase inhibitors; SAR study; Thiobarbituric acid; Rhodanine; Thiohydantoin||Issue Date:||2009||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS||Abstract:||
A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
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