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|Title:||Four-Component Reactions toward Fused Heterocyclic Rings||Authors:||Airiau, E
|Issue Date:||2009||Project:||None||Journal:||ORGANIC LETTERS||Abstract:||
A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
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