Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5583
DC FieldValueLanguage
dc.contributor.authorF., Caporuscioen_us
dc.contributor.authorTafi, Andreaen_us
dc.contributor.authorE., Gonzálezen_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorJ. A., Estéen_us
dc.contributor.authorBotta, Maurizioen_us
dc.date.accessioned2021-03-30T15:53:39Z-
dc.date.available2021-03-30T15:53:39Z-
dc.date.issued2009-
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5583-
dc.description35957en_US
dc.description.abstractA dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 was built and used to identify new hits able to inhibit gp120–CD4 protein–protein interactions. Two compounds showed micromolar inhibition of HIV-1 replication in cells attributable to an interference with the entry step of infection, by direct interaction with gp120. Inactivity of compounds toward a M475I strain suggested specific contacts with the Phe43 cavity of gp120.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofBIOORGANIC & MEDICINAL CHEMISTRY LETTERSen_US
dc.subjectProtein–protein interactions; gp120–CD4 interactions; Phe43 cavity; Structure-based drug design; Pharmacophore modelingen_US
dc.titleA dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactionsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmcl.2009.09.029en_US
dc.identifier.pmid19783140en_US
dc.identifier.scopus2-s2.0-71749107966en_US
dc.identifier.isiWOS:000270561300021en_US
dc.relation.volume19en_US
dc.description.firstpage6087en_US
dc.description.lastpage6091en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4308-3531-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0003-0456-6995-
Appears in Collections:Publications
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.