Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5521
Title: Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents.
Authors: E., Tassoni
F., Giannessi
T., Brunetti
P., Pessotto
M. L., Renzulli
Travagli, Massimiliano
S., Rajamaki
S., Prati
S., Dottori
Corelli, Federico 
W., Cabri
P., Carminati
Botta, Maurizio 
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a γ,γ-dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N′-(4-(aminomethyl)cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.
Description: 
37415
URI: http://hdl.handle.net/20.500.12779/5521
ISSN: 0022-2623
DOI: 10.1021/jm8001636
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