Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5490
Title: 1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings
Authors: Biava, M
PORRETTA G., C
Poce, G
DE LOGU, A
Saddi, M
Meleddu, R
Manetti, Fabrizio 
DE ROSSI, E
Botta, Maurizio 
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Synthesis and biological evaluation of new derivatives of 1,5-bis(4-chlorophenyl)-2-methyl-3-(4-methylpiperazin-1-yl)methyl-1H-pyrrole (BM 212, 16) are reported. Variously substituted phenyl rings with different substitution pattern and lipophilicity were added to the pyrrole nucleus to evaluate their influence on the activity toward Mycobacterium tuberculosis (MTB) and atypical mycobacteria. The most active derivatives showed activity between 0.125-0.5 μg/mL (better than 16 and streptomycin) and protection index (64-256) higher than 16 (4) and similar to isoniazid and streptomycin (128).
Description: 
37111
URI: http://hdl.handle.net/20.500.12779/5490
ISSN: 0022-2623
DOI: 10.1021/jm701560p
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