Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5483
Title: Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines.
Authors: Manetti, Fabrizio 
Brullo, C
Magnani, M
Mosci, F
Chelli, B
Crespan, E
Schenone, S
Naldini, Antonella
Bruno, O
Trincavelli, Ml
Maga, G
Carraro, Fabio
Martini, C
Bondavalli, F
Botta, Maurizio 
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-based optimization approach to improve the biological properties of pyrazolo-pyrimidine derivatives in terms of inhibition of Abl enzymatic activity and antiproliferative properties toward human leukemia cells. Insertion of halogen substituents with various substitution patterns, suggested by simulations, led to a significant improvement of leukemia cell growth inhibition and to an increase up to 1 order of magnitude of the affinity toward Abl.
Description: 
37114
URI: http://hdl.handle.net/20.500.12779/5483
ISSN: 0022-2623
DOI: 10.1021/jm701240c
Appears in Collections:Publications

Show full item record

Page view(s)

1
Last Week
0
Last month
1
checked on May 16, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.