Please use this identifier to cite or link to this item:
|Title:||Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines.||Authors:||Manetti, Fabrizio
|Issue Date:||2008||Project:||None||Journal:||JOURNAL OF MEDICINAL CHEMISTRY||Abstract:||
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-based optimization approach to improve the biological properties of pyrazolo-pyrimidine derivatives in terms of inhibition of Abl enzymatic activity and antiproliferative properties toward human leukemia cells. Insertion of halogen substituents with various substitution patterns, suggested by simulations, led to a significant improvement of leukemia cell growth inhibition and to an increase up to 1 order of magnitude of the affinity toward Abl.
|Appears in Collections:||Publications|
Show full item record
checked on May 16, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.