Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5473
Title: New Phosphorylated derivatives of carboxymethylcellulose with osteogenic activity
Authors: Leone, Gemma 
P., Torricelli
R., Giardino
Barbucci, Rolando
Keywords: polysaccharide; phosphorylation; bone regeneration
Issue Date: 2008
Project: None 
Journal: POLYMERS FOR ADVANCED TECHNOLOGIES
Abstract: 
New phosphorylated derivatives of carboxymethylcellulose (CMC) and amidic CMC were realized using trisodium trimetaphosphate (STMP) as the phosphating agent. The new polysaccharides were characterized by infrared spectroscopy and elemental analysis. The characterized polysaccharides were then crosslinked and their rheological and swelling properties determined. The presence of phosphate groups made the three-dimensional structures more compact and harder than the corresponding non-phosphated hydrogels. Evaluation of the bioactivity of phosphorylated hydrogels toward osteoblast-like cells (MG63) showed a significant increase in the osteocalcin production
Description: 
36107
URI: http://hdl.handle.net/20.500.12779/5473
ISSN: 1042-7147
DOI: 10.1002/pat.1041
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