Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5471
Title: 1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies
Authors: G., LA REGINA
F., D'Auria
Tafi, Andrea 
F., Piscitelli
S., Olla
F., Caporuscio
L., Nencioni
R., Cirilli
F., LA TORRE
N., RODRIGUES DE MELO
S., Kelly
D., Lamb
M., Artico
Botta, Maurizio 
A., Palamara
R., Silvestri
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
New 1-[(3-aryloxy-3-aryl)propyl]-1 H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives ( 10, 12, 14, 18- 20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 microg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC
Description: 
22425
URI: http://hdl.handle.net/20.500.12779/5471
ISSN: 0022-2623
DOI: 10.1021/jm800009r
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