Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5466
Title: Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation
Authors: Antonio, Garofalo
Fedora, Grande
Francesca, Aiello
Raveendra, Dayam
Nouri, Neamati
Brizzi, Antonella 
Issue Date: 2008
Project: None 
Journal: CHEMMEDCHEM
Abstract: 
HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity on cell-based assays. Due to their low cytotoxicity, low molecular weight, drug-like properties, and structural novelty, we embarked on a study to optimize the original lead compounds.
Description: 
26364
URI: http://hdl.handle.net/20.500.12779/5466
ISSN: 1860-7179
DOI: 10.1002/cmdc.200800026
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