Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5456
Title: Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis
Authors: Castagnolo, D
DE LOGU, A
Botta, Maurizio 
Bechi, B
Manetti, Fabrizio 
Magnani, M
Supino, S
Meleddu, R
Chisu, L
Botta, Maurizio 
Issue Date: 2008
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Abstract: 
As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as inhibitors of Mycobacterium tuberculosis (MTB), which is the causative agent of tuberculosis. One of these compounds showed high activity against MTB (MIC = 4 microg/mL). The newly synthesized pyrazoles were also computationally investigated to analyze their fit properties to the pharmacophoric model for antitubercular compounds previously built by us and to refine structure-activity relationship analysis.
Description: 
37113
URI: http://hdl.handle.net/20.500.12779/5456
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2008.08.016
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