Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5454
Title: An amidated carboxymethylcellulose hydrogel for cartilage regeneration
Authors: Leone, Gemma 
M., Fini
P., Torricelli
R., Giardino
Barbucci, Rolando
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE
Abstract: 
An amidic derivative of carboxymethylcellulose was synthesized (CMCA). The new polysaccharide was obtained by converting a large percentage of carboxylic groups (*50%) of carboxymethylcellulose into amidic groups rendering the macromolecule quite similar to hyaluronan. Then, the polysaccharide (CMCA) was crosslinked. The behavior of CMCA hydrogel towards normal human articular chondrocytes (NHAC) was in vitro studied monitoring the cell proliferation and synthesis of extra cellular matrix (ECM) components and compared with a hyaluronan based hydrogel (Hyal). An extracellular matrix rich in cartilage- specific collagen and proteoglycans was secreted in the presence of hydrogels. The injectability of the new hydrogels was also analysed. An experimental in vivo model was realized to study the effect ofCMCAand Hyal hydrogels in the treatment of surgically created partial thickness chondral defects in the rabbit knee. The preliminary results pointed out that CMCA hydrogel could be considered as a potential compound for cartilage regeneration.
Description: 
35706
URI: http://hdl.handle.net/20.500.12779/5454
ISSN: 0957-4530
DOI: 10.1007/s10856-008-3412-7
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