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|Title:||Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies.||Authors:||Botta, Maurizio
ARMAND UGON, M
|Keywords:||HIV-1; Reverse Transcriptase; Mutant; NNRTIs; S-DABOCs; Molecular modeling||Issue Date:||2008||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS||Abstract:||
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
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