Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5446
Title: Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors.
Authors: Pasquini, Serena
Mugnaini, Claudia 
Tintori, Cristina
Botta, Maurizio 
A., Trejos
R. K., Arvela
M., Larhed
M., Vitvrouw
M., Michiels
F., Christ
Z., Debyser
Corelli, Federico 
Issue Date: 2008
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.
Description: 
42012
URI: http://hdl.handle.net/20.500.12779/5446
ISSN: 0022-2623
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