Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5442
Title: A one-pot, two step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs)
Authors: Radi, Marco
S., Saletti
Botta, Maurizio 
Issue Date: 2008
Project: None 
Journal: TETRAHEDRON LETTERS
Abstract: 
A one-pot, two-step protocol for the microwave-assisted solid-phase synthesis of substituted benzoxazoles has been developed starting from different polymer-bound esters we previously designed as solid-supported reagents (SSRs) for the acylation of amines, alcohols and phenols. The combination of a parallel synthesizer and a microwave reactor allowed to quickly prepare a collection of substituted benzoxaxoles in high purity and satisfactory yields. This protocol is amenable for automation and could be used for the preparation of combinatorial libraries in drug discovery programs.
Description: 
22363
URI: http://hdl.handle.net/20.500.12779/5442
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.05.059
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