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|Title:||VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues.||Authors:||Bardelli, Monia
De Falco, Giulia
|Keywords:||Angiogenesis; Leukemia; Lymphoma; VEGF-D; VEGFR-3; Antibodies, Monoclonal; Biopsy; Bone Marrow Cells; Cell Line, Tumor; HL-60 Cells; Hematopoietic Stem Cells; Humans; K562 Cells; Lymph Nodes; Lymphocytes; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; Cancer Research; Hematology; Oncology||Issue Date:||2007||Project:||None||Journal:||LEUKEMIA & LYMPHOMA||Abstract:||
Vascular Endothelial Growth Factor (VEGF)-D is a member of the VEGF family of angiogenic growth factors that activate the Vascular Endothelial Growth Factor Receptor (VEGFR)-2 and VEGFR-3, which are mainly expressed in blood and lymphatic vessels. Here we have analyzed by using monoclonal antibodies, the expression of VEGF-D and its cognate receptor VEGFR-3 in normal and pathologic bone marrow and lymph node biopsies. This analysis revealed that VEGF-D is expressed in B cells of the germinal centers, scattered B and T blasts, myeloid progenitors, acute leukemia, several types of non Hodgkin lymphoma, and classical Hodgkin's lymphoma. In normal tissues VEGFR-3 was only expressed in fenestrated capillaries of bone marrow and in lymphatic vessels of lymph nodes, while in VEGF-D expressing tumors newly formed vessels, but not malignant cells, showed high VEGFR-3 expression. These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues.
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