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|Title:||Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.||Authors:||Mugnaini, Claudia
|Issue Date:||2007||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS||Abstract:||
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC(50)=12 microM.
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