Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5339
Title: A Versatile Route to C-6 Arylmethyl-Functionalized S-DABO and Related Analogues.
Authors: Botta, Maurizio 
Contemori, Lorenzo
Castagnolo, Daniele
Spinosa, Raffaella
Este, J. A.
Massa, Silvio
Botta, Maurizio 
Issue Date: 2007
Project: None 
Journal: ORGANIC LETTERS
Abstract: 
Since their discovery in 1992, 3,4-dihydro-2-alkoxy-6-benzyl-4-oxypyrimidines (DABOs) have been subjected to many structural modifications in order to obtain better non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of AIDS. Herein, we report a straightforward and versatile route for the synthesis of novel C-6 arylmethyl-functionalized S-DABO, a poorly explored class of derivatives. Finally, biological evaluation of the synthesized derivatives led to the identification of a promising anti-HIV-1 lead compound.
Description: 
38302
URI: http://hdl.handle.net/20.500.12779/5339
ISSN: 1523-7060
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