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|Title:||A Versatile Route to C-6 Arylmethyl-Functionalized S-DABO and Related Analogues.||Authors:||Botta, Maurizio
Este, J. A.
|Issue Date:||2007||Project:||None||Journal:||ORGANIC LETTERS||Abstract:||
Since their discovery in 1992, 3,4-dihydro-2-alkoxy-6-benzyl-4-oxypyrimidines (DABOs) have been subjected to many structural modifications in order to obtain better non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of AIDS. Herein, we report a straightforward and versatile route for the synthesis of novel C-6 arylmethyl-functionalized S-DABO, a poorly explored class of derivatives. Finally, biological evaluation of the synthesized derivatives led to the identification of a promising anti-HIV-1 lead compound.
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