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Title: Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.
Authors: Manetti, Fabrizio 
Santucci, Annalisa 
Locatelli, Ga
Maga, G
Spreafico, A
Serchi, T
Orlandini, Maurizio 
Bernardini, Giulia 
Caradonna, Np
Spallarossa, A
Brullo, C
Schenone, S
Bruno, O
Ranise, A
Bondavalli, F
Hoffmann, O
Bologna, M
Angelucci, A
Botta, Maurizio 
Issue Date: 2007
Project: None 
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-free assay. Some of them significantly reduced the growth of human osteogenic sarcoma (SaOS-2) cells. The best compound, in terms of inhibitory properties toward both Src and SaOS-2 cells, was further investigated and found to reduce bone resorption when used to treat mouse osteoclasts, without interfering with normal osteoblast growth. Moreover, its metabolic stability prompted its study on a human SaOS-2 xenograft tumor model in nude mice, where the compound reduced significantly both the volume and weight of the tumor. These experimental findings make the new compound an interesting hit in the field of bone-related diseases.
ISSN: 0022-2623
DOI: 10.1021/jm061449r
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