Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5324
DC FieldValueLanguage
dc.contributor.authorMartini, Sen_us
dc.contributor.authorBonechi, Claudiaen_us
dc.contributor.authorCorbini, Gianfrancoen_us
dc.contributor.authorRossi, Claudioen_us
dc.date.accessioned2021-03-30T15:50:45Z-
dc.date.available2021-03-30T15:50:45Z-
dc.date.issued2007-
dc.identifier.issn0009-2614en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5324-
dc.description36806en_US
dc.description.abstractIn this Letter we propose a development of a NMR methodology to study ligand–macromolecular receptor interactions, based on the analysis of proton selective spin-lattice relaxation rate enhancements of the ligand, to calculate an affinity index, related to strength of the interaction process. In this work we modified this index by normalization to the relaxation rate of the free ligand, in order to take into account the effects of motional anisotropies and different proton densities. This approach also allowed the calculation of the relaxation rate of the bound ligand as well as the equilibrium constant of the interaction process.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofCHEMICAL PHYSICS LETTERSen_US
dc.titleDetermination of the Modified “Affinity Index” of Small Ligands and Macromolecular Receptors from NMR Spin-lattice Relaxation Dataen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cplett.2007.09.011en_US
dc.identifier.scopus2-s2.0-34848917807en_US
dc.identifier.isiWOS:000250708000028en_US
dc.relation.volume447en_US
dc.description.firstpage147en_US
dc.description.lastpage153en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-4328-3253-
crisitem.author.orcid0000-0001-9788-564X-
crisitem.author.orcid0000-0001-6032-1015-
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