Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5324
Title: Determination of the Modified “Affinity Index” of Small Ligands and Macromolecular Receptors from NMR Spin-lattice Relaxation Data
Authors: Martini, S
Bonechi, Claudia 
Corbini, Gianfranco 
Rossi, Claudio 
Issue Date: 2007
Project: None 
Journal: CHEMICAL PHYSICS LETTERS
Abstract: 
In this Letter we propose a development of a NMR methodology to study ligand–macromolecular receptor interactions, based on the analysis of proton selective spin-lattice relaxation rate enhancements of the ligand, to calculate an affinity index, related to strength of the interaction process. In this work we modified this index by normalization to the relaxation rate of the free ligand, in order to take into account the effects of motional anisotropies and different proton densities. This approach also allowed the calculation of the relaxation rate of the bound ligand as well as the equilibrium constant of the interaction process.
Description: 
36806
URI: http://hdl.handle.net/20.500.12779/5324
ISSN: 0009-2614
DOI: 10.1016/j.cplett.2007.09.011
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