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|Title:||Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.||Authors:||Maga, G
|Issue Date:||2007||Project:||None||Journal:||ANGEWANDTE CHEMIE. INTERNATIONAL EDITION||Abstract:||
How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
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