Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5317
Title: Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.
Authors: Maga, G
Botta, Maurizio 
Zanoli, S
Manetti, Fabrizio 
Cancio, R
Hübscher, U
Spadari, S
Falciani, C
Terrazas, M
Vilarrasa, J
Botta, Maurizio 
Issue Date: 2007
Project: None 
Journal: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
Abstract: 
How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
Description: 
38093
URI: http://hdl.handle.net/20.500.12779/5317
ISSN: 1433-7851
DOI: 10.1002/anie.200604165
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