Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5314
Title: Helicobacter pylori: immunoproteomics related to different pathologies
Authors: Bernardini, Giulia 
Braconi, Daniela 
Lusini, Paola
Santucci, Annalisa 
Issue Date: 2007
Project: None 
Journal: EXPERT REVIEW OF PROTEOMICS
Abstract: 
Helicobacter pylori is a Gram-negative bacterium that causes ulcer, atrophic gastritis, adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Moreover, an ongoing controversial role of this bacterium infection has been suggested in the etiopathogenesis of some extradigestive diseases. The humoral response to H. pylori during a natural infection can be used for diagnostic purposes and as a basis for vaccine development. Host-pathogen interactions may be investigated by means of immunoproteomics, which provides global information about relevant specific and nonspecific antigens, and thus might be suitable to identify novel vaccine candidates or serological markers of H. pylori infection as well as of different related diseases. In this review, we describe how several research groups used H. pylori proteomics combined with western blotting analysis, using sera from patients affected with different H. pylori-related pathologies, to investigate potential associations between host immune response and clinical outcomes of H. pylori infection, resulting in the rapid identification of novel, highly immunoreactive antigens.
Description: 
35008
URI: http://hdl.handle.net/20.500.12779/5314
ISSN: 1478-9450
DOI: 10.1586/14789450.4.5.679
Appears in Collections:Publications

Show full item record

Page view(s)

1
Last Week
1
Last month
1
checked on May 9, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.