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|Title:||An approach to address Candida rugosa lipase regioselectivity in the acylation reactions of trytilated glucosides||Authors:||C., Palocci
|Issue Date:||2007||Project:||None||Journal:||JOURNAL OF BIOTECHNOLOGY||Abstract:||
Candida rugosa lipase crude preparations (CRL) catalyse the regioselective acylation of methyl 6-O-trytil beta-D-glucopyranoside in organic solvents, using vinyl acetate as acyl donor, The ratio of the two products formed, namely methyl 2-O acetyl 6-O-trytil beta-D-glucopyranoside and methyl 3-O acetyl 6-O-trytil beta-D-glucopyranoside was found to be markedly affected by the nature of the reaction medium. In hydrophobic solvents values up to 80% of the monoacetylated product in position C-3 were obtained compared to less than 30% in solvents with low hydrophobicity. Computational studies were carried out to simulate the interactions between methyl 6-O-trytil beta-D-glucopyranoside and both CRL and the solvents, in order to rationalize the experimental results. (c) 2007 Elsevier B.V. All rights reserved.
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