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|Title:||Cyclodextrins as cosmetic delivery systems.||Authors:||Centini, Marisanna
MAFFEI FACINO, R
|Keywords:||CDs inclusion complexes; Ferulic acid; Photostability; Radical scavenging activity; Release||Issue Date:||2007||Project:||None||Journal:||JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY||Abstract:||
Aim of this work was the study of ferulicacid/cyclodextrin (CD) association complexes. Ferulicacid (FA) is a compound well-known as antioxidantand photoprotective agent (approved in Japan as sunscreen).Notwithstanding this, it is poorly suited forcosmetic applications because it undergoes functionaland organoleptic modifications, when it is exposed toair, UV-light and heat. For this reason we prepared aset of FA/CD complexes with the aim to improve itsphysico-chemical stability. The inclusion complexeswere characterized by differential scanning calorimetry(DSC), X-ray diffraction (XRD), and nuclear magneticresonance (1H-NMR). The FA/a-CD complex showedthe most promising properties (high association constant,high degree of photostability, slower FA release)as sunscreen delivery system.
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