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|Title:||‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’||Authors:||Botta, Maurizio
|Issue Date:||2007||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS||Abstract:||
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
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