Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5229
DC FieldValueLanguage
dc.contributor.authorBetti, L.en_us
dc.contributor.authorZanelli, M.en_us
dc.contributor.authorGiannaccini, G.en_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorSchenone, S.en_us
dc.contributor.authorStrappaghetti, G.en_us
dc.date.accessioned2021-03-30T15:50:05Z-
dc.date.available2021-03-30T15:50:05Z-
dc.date.issued2006-
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5229-
dc.description24961en_US
dc.description.abstractWe report the design and synthesis of a new class of piperazine- pyridazinone analogues. The arylpiperazine moiety, the length of the spacer, and the terminal molecular fragment were varied to evaluate their influence in determining the affinity of the new compounds toward the α1- adrenergic receptor (α1-AR), α2-adrenergic receptor (α2-AR), and the 5-HT1A serotoninergic receptor (5-HT1AR). Biological data showed that most of the compounds have an α1-AR affinity in the nanomolar or subnanomolar range, while affinity toward the other two receptors was lower in most cases. However, several of the tested compounds also showed very good (in the nanomolar range) or moderate affinity toward the 5-HT1AR subtype.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofBIOORGANIC & MEDICINAL CHEMISTRYen_US
dc.subjectα-Adrenergic receptor ligands; 5-HT1A receptor ligands; Arylalkylpiperazines; Piperazine-pyridazinonesen_US
dc.titleSynthesis of New Piperazine-pyridazinone Derivatives and their Binding Affinity toward alpha1-, alpha2-Adrenergic and 5-HT-1A Serotoninergic Receptorsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmc.2005.12.009en_US
dc.identifier.pmid16376083en_US
dc.identifier.scopus2-s2.0-33644749171en_US
dc.identifier.isiWOS:000236264800037en_US
dc.relation.volume14en_US
dc.relation.issue8en_US
dc.description.firstpage2828en_US
dc.description.lastpage2836en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-9598-2339-
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