Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5228
DC FieldValueLanguage
dc.contributor.authorCarraro, Fabioen_us
dc.contributor.authorNaldini, Antonellaen_us
dc.contributor.authorPucci, Annalisaen_us
dc.contributor.authorLocatelli, Gaen_us
dc.contributor.authorMaga, Gen_us
dc.contributor.authorSchenone, Sen_us
dc.contributor.authorBruno, Oen_us
dc.contributor.authorRanise, Aen_us
dc.contributor.authorBondavalli, Fen_us
dc.contributor.authorBrullo, Cen_us
dc.contributor.authorFossa, Pen_us
dc.contributor.authorMenozzi, Gen_us
dc.contributor.authorMosti, Len_us
dc.contributor.authorModugno, Men_us
dc.contributor.authorTintori, Cristinaen_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorBotta, Maurizioen_us
dc.date.accessioned2021-03-30T15:50:04Z-
dc.date.available2021-03-30T15:50:04Z-
dc.date.issued2006-
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5228-
dc.description37663en_US
dc.description.abstractWe report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation (A431 and 8701-BC cells). Such compounds block the growth of cancer cells by interfering with the phosphorylation of Src, and they act as proapoptotic agents through the inhibition of the anti apoptotic gene BCL2. Several of them were found to be more active than the reference compound (1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine, PP2) in inhibiting cell proliferation and in inducing apoptosis, and as active as PP2 in the inhibition of the phosphorylation of isolated Src. Moreover, molecular modeling simulations have been performed to hypothesize the way, at the molecular level, by which the inhibitors were able to act as antiproliferative agents.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofJOURNAL OF MEDICINAL CHEMISTRYen_US
dc.titlePyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.en_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm050603ren_US
dc.identifier.pmid16509573en_US
dc.identifier.scopus2-s2.0-33644869311en_US
dc.identifier.isiWOS:000236005400008en_US
dc.relation.volume49en_US
dc.relation.issue5en_US
dc.description.firstpage1549en_US
dc.description.lastpage1561en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0003-0456-6995-
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