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|Title:||In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands||Authors:||M. G., Cascio
M., VAN DER STELT
V., DE NOVELLIS
T., VAN DE DOELEN
V., DI MARZO
|Issue Date:||2006||Project:||None||Journal:||BRITISH JOURNAL OF PHARMACOLOGY||Abstract:||
We have previously reported the development of CB-25 and CB-52, two ligands of CB1 and CB2 cannabinoid receptors. We assessed here their functional activity. The effect of the two compounds on forskolin-induced cAMP formation in intact cells or GTP-g-S binding to cell membranes, and their action on nociception in vivo was determined.
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