Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5216
Title: Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase
Authors: Calderone, V
Casini, A
Mangani, Stefano 
Messori, L
Orioli, Pl
Keywords: antitumor agents, cisplatin, platinum, superoxide dismutase, X-ray diffraction
Issue Date: 2006
Project: None 
Journal: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
Abstract: 
The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands.
Description: 
21828
URI: http://hdl.handle.net/20.500.12779/5216
ISSN: 1433-7851
DOI: 10.1002/anie.200502599
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.