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|Title:||Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors||Authors:||Mugnaini, Claudia
EST J., A
CLOTET CODINA, I
|Issue Date:||2006||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS||Abstract:||
S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
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