Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5193
Title: Tertiary structure prediction of SARS coronavirus helicase
Authors: Bernini, Andrea 
Spiga, Ottavia 
V., Venditti
F., Prischi
Bracci, Luisa
J. D., Huang
J. A., Tanner
Niccolai, Neri 
Issue Date: 2006
Project: None 
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Abstract: 
SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.
Description: 
47317
URI: http://hdl.handle.net/20.500.12779/5193
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.03.069
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