Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5192
Title: Synthesis and antitumor activities of a series of novel quinoxalinhydrazides
Authors: F., Grande
F., Aiello
O., DE GRAZIA
Brizzi, Antonella 
A., Garofalo
N., Neamati
Issue Date: 2006
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Abstract: 
Recently, we discovered a novel class of anticancer compounds with remarkable potency in a panel of cancer cell lines. A prototype compound, SC144, showed significant in vivo efficacy in mice xenograft models of human breast cancer cells. Herein, we report on a new synthetic route to SC144 and the synthesis of several of its analogues in order to understand required features for activity. A one-step coupling of 7-fluoro-4-chloropyrrolo[1,2-a]quinoxaline with pyrazin-2-carbohydrazide improved the yield significantly. Although several of the analogues showed significant activities, modification of the heteroacyl moiety had a dramatic effect on potency.
Description: 
26344
URI: http://hdl.handle.net/20.500.12779/5192
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2006.09.073
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