Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5174
DC FieldValueLanguage
dc.contributor.authorF., Aielloen_us
dc.contributor.authorBrizzi, Antonellaen_us
dc.contributor.authorO., DE GRAZIAen_us
dc.contributor.authorA., Garofaloen_us
dc.contributor.authorF., Grandeen_us
dc.contributor.authorM. S., Sinicropien_us
dc.contributor.authorR., Dayamen_us
dc.contributor.authorN., Neamatien_us
dc.date.accessioned2021-03-30T15:49:38Z-
dc.date.available2021-03-30T15:49:38Z-
dc.date.issued2006-
dc.identifier.issn0223-5234en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5174-
dc.description26342en_US
dc.description.abstractHerein, we describe a new strategy for the preparation of thiazolothiazepine-based inhibitors of human immunodeficiency virus type-1 integrase (IN). The present method allows facile preparation of the title compounds in a single enantiomeric form starting from l-4-thiazolidinecarboxylic acid. This method could be easily extended to the synthesis of several analogs derived from optically active cyclic aminoacids. We also present a putative model showing the interaction between l- and d-isomers of compound 1 in the IN active site. A sensibly lower IC(50) value was found for (-)-1 over racemic-1 in an anti-IN assay.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYen_US
dc.titleAn approach to the stereo-controlled synthesis of polycyclic derivatives of L-4-thiazolidinecarboxilic acid active against HIV-1 integraseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejmech.2006.03.032en_US
dc.identifier.pmid16781021en_US
dc.identifier.scopus2-s2.0-33746860432en_US
dc.identifier.isiWOS:000240213700002en_US
dc.relation.volume41en_US
dc.description.firstpage914en_US
dc.description.lastpage917en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-2310-9899-
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