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|Title:||Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies||Authors:||Mini, R
|Issue Date:||2006||Project:||None||Journal:||JOURNAL OF CHROMATOGRAPHY. B||Abstract:||
Helicobacter pylori is a Gram-negative bacterium which causes ulcer, atrophic gastritis, adenocarcinoma, or mucosa-associated lymphoid tissue lymphoma. A comparative proteomic and immunoproteomic analysis was chosen to identify the antigenic patterns of three different H. pylori strains. These strains were probed against single sera from H. pylori-positive patients affected by gastric adenocarcinoma or duodenal ulcer. We found a quite heterogeneous antigenic pattern, both from strain and sera points of view, thus underlying both a strain- and a host-specificity. The different antigenic repertoires introduced the importance of the strain to be used for immunoblotting as a diagnostic test.
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