Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5172
Title: Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies
Authors: Mini, R
Bernardini, Giulia 
Salzano, Am
Renzone, G
Scaloni, A
Figura, Natale
Santucci, Annalisa 
Issue Date: 2006
Project: None 
Journal: JOURNAL OF CHROMATOGRAPHY. B
Abstract: 
Helicobacter pylori is a Gram-negative bacterium which causes ulcer, atrophic gastritis, adenocarcinoma, or mucosa-associated lymphoid tissue lymphoma. A comparative proteomic and immunoproteomic analysis was chosen to identify the antigenic patterns of three different H. pylori strains. These strains were probed against single sera from H. pylori-positive patients affected by gastric adenocarcinoma or duodenal ulcer. We found a quite heterogeneous antigenic pattern, both from strain and sera points of view, thus underlying both a strain- and a host-specificity. The different antigenic repertoires introduced the importance of the strain to be used for immunoblotting as a diagnostic test.
Description: 
37279
URI: http://hdl.handle.net/20.500.12779/5172
ISSN: 1570-0232
DOI: 10.1016/j.jchromb.2005.12.052
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