Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5168
DC FieldValueLanguage
dc.contributor.authorAnselmi, Ceciliaen_us
dc.contributor.authorCentini, Marisannaen_us
dc.contributor.authorM., Riccien_us
dc.contributor.authorA., Buonocoreen_us
dc.contributor.authorP., Granataen_us
dc.contributor.authorT., Tsunoen_us
dc.contributor.authorR., MAFFEI FACINOen_us
dc.date.accessioned2021-03-30T15:49:34Z-
dc.date.available2021-03-30T15:49:34Z-
dc.date.issued2006-
dc.identifier.issn0731-7085en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5168-
dc.description35138en_US
dc.description.abstractFerulic acid (FA) is a well-known antioxidant of natural source with promising properties as photoprotective agent (approved in Japan assunscreen) and its derivatives (alkyl ferulates) are under screening for the prevention of photoinduced skin tumours.In the present work we describe the preparation of a solid inclusion complex between ferulic acid and -cyclodextrin (-CD) and its characterizationby different analytical techniques: differential scanning calorimetry (DSC), X-ray diffractometry (XRD), nuclear magnetic resonancespectroscopy (1H NMR) and by supporting information of molecular modelling. All these approaches indicate that ferulic acid is able to form anassociation complex with -CD but only 1H NMR and molecular modelling studies give an unequivocal evidence that the antioxidant moleculeis embedded into the -CD cavity to form an inclusion complex. In detail it is entrapped inside the hydrophobic core of -CD with the lipophilicaromatic ring and the ethylenic moieties, leaving the more polar functional groups close to wider rim or outside the cavity.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.subjectFerulic acid; gamma-CD inclusion complex; DSC; XRD analyses; 1H NMR; Molecular modelling studiesen_US
dc.titleAnalytical characterization of a ferulic acid/gamma-cyclodextrin inclusion complexen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jpba.2005.08.019en_US
dc.identifier.pmid16239093en_US
dc.identifier.scopus2-s2.0-32944477534en_US
dc.identifier.isiWOS:000236344100008en_US
dc.relation.volume40en_US
dc.relation.issue4en_US
dc.description.firstpage875en_US
dc.description.lastpage881en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-3993-8234-
Appears in Collections:Publications
Show simple item record

Page view(s)

27
Last Week
0
Last month
19
checked on Jun 17, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.