Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5168
Title: Analytical characterization of a ferulic acid/gamma-cyclodextrin inclusion complex
Authors: Anselmi, Cecilia
Centini, Marisanna 
M., Ricci
A., Buonocore
P., Granata
T., Tsuno
R., MAFFEI FACINO
Keywords: Ferulic acid; gamma-CD inclusion complex; DSC; XRD analyses; 1H NMR; Molecular modelling studies
Issue Date: 2006
Project: None 
Journal: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Abstract: 
Ferulic acid (FA) is a well-known antioxidant of natural source with promising properties as photoprotective agent (approved in Japan assunscreen) and its derivatives (alkyl ferulates) are under screening for the prevention of photoinduced skin tumours.In the present work we describe the preparation of a solid inclusion complex between ferulic acid and -cyclodextrin (-CD) and its characterizationby different analytical techniques: differential scanning calorimetry (DSC), X-ray diffractometry (XRD), nuclear magnetic resonancespectroscopy (1H NMR) and by supporting information of molecular modelling. All these approaches indicate that ferulic acid is able to form anassociation complex with -CD but only 1H NMR and molecular modelling studies give an unequivocal evidence that the antioxidant moleculeis embedded into the -CD cavity to form an inclusion complex. In detail it is entrapped inside the hydrophobic core of -CD with the lipophilicaromatic ring and the ethylenic moieties, leaving the more polar functional groups close to wider rim or outside the cavity.
Description: 
35138
URI: http://hdl.handle.net/20.500.12779/5168
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2005.08.019
Appears in Collections:Publications

Show full item record

Page view(s)

20
Last Week
8
Last month
8
checked on May 15, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.