Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5160
Title: A proteomic study of human osteoblastic cells proliferation and differentiation
Authors: Spreafico, A
Frediani, B
Capperucci, C
Chellini, F
Paffetti, Alessandro 
D'Ambrosio, A
Bernardini, Giulia 
Mini, R
Collodel, G
Scaloni, A
Marcolongo, R
Santucci, Annalisa 
Issue Date: 2006
Project: None 
Journal: PROTEOMICS
Abstract: 
Changes in expression profiles for 17 proteins were ascertained in human mature osteoblasts compared to pre-osteoblasts (differentiation markers). A differential approach was used to highlight proteomic changes between human osteosarcoma cells and mature osteoblasts, showing a relative over-expression of 8 proteins (proliferation and tumor indicators), as well as under-expression of proteins also found down-regulated in pre-osteoblasts (specific markers of osteoblast differentiation). Our findings confirmed the differences between cell lines and primary human cell cultures and suggested caution on the use of osteosarcoma to study anti-osteoporotic drugs in humans.
Description: 
36412
URI: http://hdl.handle.net/20.500.12779/5160
ISSN: 1615-9853
DOI: 10.1002/pmic.200500858
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