Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5088
Title: Unusual binding ability of vancomycin towards Cu2+ ions.
Authors: Swiatek, M
Valensin, Daniela 
Migliorini, Caterina
Gaggelli, Elena 
Valensin, Gianni 
JEZOWSKA BOJCZUK, M.
Issue Date: 2005
Project: None 
Journal: DALTON TRANSACTIONS
Abstract: 
Vancomycin, a “last chance” antibiotic, is a glycopeptide consisting of an oligopeptide unit being potentially the effective binder of Cu2+ ions. The potentiometric and spectroscopic studies (UV-Vis, CD, EPR, NMR) have shown that, indeed, the peptide unit binds cupric ions very effectively forming almost instantly the 3N complex involving the N-terminal nitrogen donors in the metal ion coordination. The comparison of the binding ability of vancomycin with other peptide chelators clearly shows the efficiency of this antibiotic in metal ion coordination. It is very likely that Cu2+ ions may play a crucial role in the pharmacology of vancomycin, particularly when administered in high doses.
Description: 
36347
URI: http://hdl.handle.net/20.500.12779/5088
ISSN: 1477-9226
DOI: 10.1039/b508662k
Appears in Collections:Publications

Show full item record

Page view(s)

470
Last Week
161
Last month
161
checked on May 12, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.